clomid pct dosage The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 debrisoquin hydroxylase is reduced in a subset of the Caucasian population about 7 to 10 of Caucasians are so-called poor metabolizers ; reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available.