In a study of the blood pressure effects of tadalafil coupled with either of two О±-blockers, doxazosin Cardura ; Pfizer, New York, NY, USA and tamsulosin Flomax ; Boehringer Ingelheim, Ridgefield, CT, USA , the hypotensive effect of doxazosin was exaggerated by almost 10 mmHg with tadalafil while there was no change in blood pressure with tamsulosin and tadalafil Kloner et al 2004
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