Patients were divided into three strata patients who did not respond to tamoxifen or progressed after disease stabilisation SD for less than 6 months stratum 1; patients who, after an initial response or SD lasting at least 6 months, experienced disease progression whilst on tamoxifen stratum 2; patients with recurrent metastatic disease during or within 12 months of discontinuing adjuvant tamoxifen stratum 3
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